Many human diseases are intermingled by the genetic mutations and environmental influences. Brain, the most complex organ in humans, is vulnerable to genetic mutations as well as extreme environmental stimuli. As the coordinator between the genome and the environment, the epigenome undergoes dynamic changes during brain activities. Several epigenetic modifier genes have been shown to […]
Memory is fascinating as it enables time travel without Theory of Relativity. A century ago Richard Semon coined the term of engram to describe a unit of cognitive information inside the brain by which memories are stored as biophysical or biochemical changes in the brain in response to external stimuli. Regardless of this terminology, human […]
Many breakthroughs in biomedical research were enabled by innovative technology and tool development, which is certainly applicable to the field of epigenetics. Traditionally epigenetics is referred to the study of heritable changes of gene expression without altering the DNA sequence during cell proliferation and development. Several molecular mechanisms including DNA methylation, histone modifications, non-coding RNAs […]